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Free heme has also been shown to promote inflammatory gene transcription in macrophages via TLR4 and NLRP3 inflammasome signaling, which have both been implicated in worsened atherosclerosis 72,73,74,75 (Fig

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5 Traditional Chinese medicine in the treatment of AMS 5.1 Understanding AMS in traditional Chinese medicine theory The body inhales insufficient pure air from the external high altitude conditions, which can easily lead to shortness of qi or qi deficiency in the body

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This activation of the NF-B signaling pathway provides a pre-excitation signal for cells, upregulating pro-inflammatory cytokines TNF - , IL-6 and chemokines (such as il-8/cxcl8)